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TargetAngiotensin II receptor
LigandBDBM50030710
Substrate/Competitorn/a
Meas. Tech.ChEMBL_36952
IC50 0.14±n/a nM
Citation Chang LLAshton WTFlanagan KLChen TBO'Malley SSZingaro GJKivlighn SDSiegl PKLotti VJChang RS Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem 38:3741-58 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Angiotensin II receptor
Name:Angiotensin II receptor
Synonyms:AT1 | AT1AR | AT1BR | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:Protein
Mol. Mass.:41080.75
Organism:Homo sapiens (Human)
Description:P30556
Residue:359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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  Blast E-value cutoff:
BDBM50030710
n/a
NameBDBM50030710
Synonyms:CHEMBL332909 | N-{3-[4-(2'-Benzoylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-butyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-propionamide
TypeSmall organic molecule
Emp. Form.C36H33F4N5O5S
Mol. Mass.723.736
SMILESCCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Structure
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