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TargetNeutrophil elastase
LigandBDBM50031193
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63969 (CHEMBL677437)
Ki 0.6±n/a nM
Citation Edwards, PDZottola, MADavis, MWilliams, JTuthill, PA Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles. J Med Chem38:3972-82 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50031193
n/a
NameBDBM50031193
Synonyms:1-[2-(4-Benzenesulfonamido-carbamide-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid [1-(benzooxazole-2-carbonyl)-2-methyl-propyl]-amide | CHEMBL128499
TypeSmall organic molecule
Emp. Form.C36H40N6O8S
Mol. Mass.716.803
SMILESCC(C)[C@H](NC(=O)c1ccc(NC(=O)NS(=O)(=O)c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)c1nc2ccccc2o1
Structure
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