| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-mannosidase |
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| Ligand | BDBM50031483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_32498 (CHEMBL641375) |
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| IC50 | <50000±n/a nM |
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| Citation |  Asano, N; Kizu, H; Oseki, K; Tomioka, E; Matsui, K; Okamoto, M; Baba, M N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. J Med Chem38:2349-56 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-mannosidase |
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| Name: | Alpha-mannosidase |
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| Synonyms: | Mannosidase 2, alpha B1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 114350.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_32498 |
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| Residue: | 1009 |
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| Sequence: | MGTGSLAPGVRAGGGNTGWLWMSSCNLGLPVLSISFLIWLLLAAPGAQAAGYKTCPTTKP
GMLNVHLLPHTHDDVGWLKTVDQYYYGIMSDVQHASVQYILDSVIYSLLNDPTRRFIYVE
MAFFSRWWKQQTNVTQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQ
DTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKFNRKRKLKMEELWR
ASASLKPPAADLFTGVLPNNYNPPKDLCWDVLCTDPPVVDDPTSPEFNANKLVDYFLNLA
SSQKKYYRTNHTVMTMGSDFQYENANMWFKNMDKLIRLVNEQQANGSKVHVLYSTPSCYL
WELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
PEAKVGPYGSGDSAPLNEAMAVLQHHDAVTGTARQNVVNDYAKQLAAGWGPCEVLVSNAL
ARLSLYKQNFSFCREINISICPASQTSEHFRVIIYNPVGRKVDLMVRLPVSEGIFLVKDP
NDRRISSNVVMVPSAYSKTYQWELLFPASVPALGFSIYSVNKMSGHNHQAHNLTARPKKS
KSRVLVIENKYIRATFDSDTGLLRKIENLEQNISLPVRQGFFWYNASAGDEESPQASGAY
IFRPSHRKPLPVSHWAQVTLVKTNLVQEVHQNFSAWCSQVIRLYEGQRHLELEWTVGPIP
VKDDWGKEVISRFNTPMRTRGQFFTDSNGREILKRRDDFRPTWTLNQTEPVAGNYYPVNT
RIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHRRLLVDDERGVAEPLLETDTGDKVRG
RHLVILSSVSDAAARHRLLAEQEVLAPQVVLAHGGSSPYHSQAPKMQFSALRRELPPQVH
LLTLARWGPKMLLLRLEHQFAVKEDSNRNLSSPVTLNLQNLFKTFTINYLQETTLAANQP
LSRVSRLKWMTDTGPISYPAPSRLDPTSITLQPMQIRTFLASVQWQRLI
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| BDBM50031483 |
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| n/a |
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| Name | BDBM50031483 |
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| Synonyms: | (2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrrolidine-3,4-diol | CHEMBL310231 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H15NO4 |
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| Mol. Mass. | 177.1983 |
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| SMILES | CN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO |
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| Structure | 
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