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TargetAngiotensin II receptor
LigandBDBM50031963
Substrate/Competitorn/a
Meas. Tech.ChEMBL_36797
Ki 4.3±n/a nM
Citation Kiyama RHonma THayashi KOgawa MHara MFujimoto MFujishita T Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique. J Med Chem 38:2728-41 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Angiotensin II receptor
Name:Angiotensin II receptor
Synonyms:AT1 | AT1AR | AT1BR | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:Protein
Mol. Mass.:41080.75
Organism:Homo sapiens (Human)
Description:P30556
Residue:359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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BDBM50031963
n/a
NameBDBM50031963
Synonyms:2,6-Dimethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethoxy]-nicotinic acid ethyl ester | CHEMBL330109
TypeSmall organic molecule
Emp. Form.C27H23N5O4
Mol. Mass.481.5026
SMILESCCOC(=O)c1c(C)nc(C)cc1OCc1ccc2c(cc3ccccc3c(=O)c2c1)-c1nnn[nH]1
Structure
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