| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Ligand | BDBM50032118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_76069 (CHEMBL688290) |
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| IC50 | 95±n/a nM |
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| Citation |  Ife, RJ; Brown, TH; Blurton, P; Keeling, DJ; Leach, CA; Meeson, ML; Parsons, ME; Theobald, CJ Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines. J Med Chem38:2763-73 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Name: | Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Synonyms: | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1/beta chain |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 0 components. |
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| Component 1 |
| Name: | Potassium-transporting ATPase subunit beta |
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| Synonyms: | ATP4B | ATP4B_PIG | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase beta chain | Potassium-transporting ATPase subunit beta | Proton pump beta chain | gp60-90 |
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| Type: | n/a |
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| Mol. Mass.: | 33083.09 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | n/a |
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| Residue: | 290 |
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| Sequence: | MAALQEKKSCSQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMSGIFALCIY
VLMRTIDPYTPDYQDQLKSPGVTLRPDVYGEKGLDISYNVSDSTTWAGLAHTLHRFLAGY
SPAAQEGSINCTSEKYFFQESFLAPNHTKFSCKFTADMLQNCSGRPDPTFGFAEGKPCFI
IKMNRIVKFLPGNSTAPRVDCAFLDQPRDGPPLQVEYFPANGTYSLHYFPYYGKKAQPHY
SNPLVAAKLLNVPRNRDVVIVCKILAEHVSFDNPHDPYEGKVEFKLKIQK
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| Component 2 |
| Name: | Potassium-transporting ATPase alpha chain 1 |
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| Synonyms: | ATP4A | ATP4A_PIG | Gastric H(+)/K(+) ATPase subunit alpha | H+/K+-ATPase | Na/K-ATPase | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump |
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| Type: | Enzyme |
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| Mol. Mass.: | 114279.23 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P19156 |
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| Residue: | 1034 |
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| Sequence: | MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAE
LEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAI
CLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQAT
VIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPE
CTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEH
FVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKR
LASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQT
FDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGY
RERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPL
DEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVS
MIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRV
PVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGA
IVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFD
NLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESD
IMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQW
ENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFF
RNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGV
RCCPGSWWDQELYY
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| BDBM50032118 |
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| n/a |
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| Name | BDBM50032118 |
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| Synonyms: | CHEMBL93369 | N*2*-(4-Fluoro-2-methyl-phenyl)-8-methoxy-N*4*-methyl-N*4*-o-tolyl-quinazoline-2,4-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23FN4O |
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| Mol. Mass. | 402.464 |
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| SMILES | COc1cccc2c(nc(Nc3ccc(F)cc3C)nc12)N(C)c1ccccc1C |
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| Structure | 
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