| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM1361 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196795 (CHEMBL802186) |
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| IC50 | 150±n/a nM |
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| Citation |  Schäfer, W; Friebe, WG; Leinert, H; Mertens, A; Poll, T; von der Saal, W; Zilch, H; Nuber, B; Ziegler, ML Non-nucleoside inhibitors of HIV-1 reverse transcriptase: molecular modeling and X-ray structure investigations. J Med Chem36:726-32 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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|
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| BDBM1361 |
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| n/a |
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| Name | BDBM1361 |
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| Synonyms: | 9b-(naphthalen-1-yl)-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol-5-one | CHEMBL87303 | Thiazoloisoindol-5-one deriv. 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15NOS |
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| Mol. Mass. | 317.404 |
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| SMILES | O=C1N2CCSC2(c2ccccc12)c1cccc2ccccc12 |
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| Structure | 
|
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