Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50033978 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_28792 (CHEMBL641702) |
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IC50 | 70.0±n/a nM |
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Citation | Maduskuie, TP; Wilde, RG; Billheimer, JT; Cromley, DA; Germain, S; Gillies, PJ; Higley, CA; Johnson, AL; Pennev, P; Shimshick, EJ Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors. J Med Chem38:1067-83 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
Type: | PROTEIN |
Mol. Mass.: | 64165.56 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_28796 |
Residue: | 545 |
Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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BDBM50033978 |
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n/a |
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Name | BDBM50033978 |
Synonyms: | 1-{5-[4,5-Bis-(4-methylsulfanyl-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-3-(2,4-difluoro-phenyl)-1-heptyl-urea | CHEMBL275479 |
Type | Small organic molecule |
Emp. Form. | C36H44F2N4OS3 |
Mol. Mass. | 682.953 |
SMILES | CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(SC)cc1)-c1ccc(SC)cc1)C(=O)Nc1ccc(F)cc1F |
Structure |
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