| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50034707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_83924 (CHEMBL693689) |
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| Ki | >10000±n/a nM |
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| Citation |  Shih, NY; Lupo, AT; Aslanian, R; Orlando, S; Piwinski, JJ; Green, MJ; Ganguly, AK; Clark, MA; Tozzi, S; Kreutner, W A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist. J Med Chem38:1593-9 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50034707 |
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| n/a |
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| Name | BDBM50034707 |
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| Synonyms: | 4-((2S,3R)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole | CHEMBL18980 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H13N3 |
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| Mol. Mass. | 151.2089 |
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| SMILES | C[C@@H]1NCC[C@H]1c1cnc[nH]1 |
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| Structure | 
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