Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50035498 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63962 (CHEMBL677431) |
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Ki | 12±n/a nM |
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Citation | Burkhart, JP; Koehl, JR; Mehdi, S; Durham, SL; Janusz, MJ; Huber, EW; Angelastro, MR; Sunder, S; Metz, WA; Shum, PW Inhibition of human neutrophil elastase. 3. An orally active enol acetate prodrug. J Med Chem38:223-33 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50035498 |
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n/a |
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Name | BDBM50035498 |
Synonyms: | (S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzoylamino]-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL76669 |
Type | Small organic molecule |
Emp. Form. | C28H37F3N4O6 |
Mol. Mass. | 582.6118 |
SMILES | CC(C)[C@H](NC(=O)c1ccc(cc1)C(=O)N1CCOCC1)C(=O)N1CCC[C@H]1C(=O)NC(C(C)C)C(=O)C(F)(F)F |
Structure |
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