Reaction Details |
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Target | DNA topoisomerase 1 |
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Ligand | BDBM50036132 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53717 (CHEMBL663645) |
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IC50 | 11±n/a nM |
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Citation | Luzzio, MJ; Besterman, JM; Emerson, DL; Evans, MG; Lackey, K; Leitner, PL; McIntyre, G; Morton, B; Myers, PL; Peel, M Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem38:395-401 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 1 |
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Name: | DNA topoisomerase 1 |
Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 90771.02 |
Organism: | Homo sapiens (Human) |
Description: | P11387 |
Residue: | 765 |
Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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BDBM50036132 |
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n/a |
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Name | BDBM50036132 |
Synonyms: | 15-chloromethyl-8-ethyl-8-hydroxy-(8S)-2,3,8,9,12,14-hexahydro-11H-[1,4]dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12-dione | CHEMBL338843 |
Type | Small organic molecule |
Emp. Form. | C23H19ClN2O6 |
Mol. Mass. | 454.86 |
SMILES | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5OCCOc5cc4c(CCl)c3Cn1c2=O |
Structure |
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