| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-citrate synthase |
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| Ligand | BDBM50036210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_29524 (CHEMBL640440) |
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| Ki | 150±n/a nM |
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| Citation |  Dolle, RE; Gribble, A; Wilkes, T; Kruse, LI; Eggleston, D; Saxty, BA; Wells, TN; Groot, PH Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase. J Med Chem38:537-43 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| ATP-citrate synthase |
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| Name: | ATP-citrate synthase |
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| Synonyms: | ACLY_RAT | Acly |
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| Type: | PROTEIN |
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| Mol. Mass.: | 120645.65 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_857791 |
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| Residue: | 1100 |
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| Sequence: | MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPD
QLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFY
VCIYATREGDYVLFHHEGGVDVGDVDTKAQKLLVGVDEKLNAEDIKRHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGSLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMAWA
PAIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPS
PRSLQGKSATLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKF
YWGHKEILIPVFKNMADAMKKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGI
PEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVS
RSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGG
TEEYKICRGIKEGRLTKPVVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKE
AGVFVPRSFDELGEIIQSVYEDLVAKGAIVPAQEVPPPTVPMDYSWARELGLIRKPASFM
TSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQRRLPKYSCQFIEMCLMVTADHG
PAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVN
KMKKEGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFPATPLLDYALEVEKITTSKKPNL
ILNVDGFIGVAFVDMLRNCGSFTREEADEYVDIGALNGVFVLGRSMGFIGHYLDQKRLKQ
GLYRHPWDDISYVLPEHMSM
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| BDBM50036210 |
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| n/a |
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| Name | BDBM50036210 |
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| Synonyms: | (2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid | CHEMBL118715 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8O8 |
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| Mol. Mass. | 208.1229 |
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| SMILES | O[C@H](C(O)=O)[C@@](O)(CC(O)=O)C(O)=O |
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| Structure | 
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