| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50036257 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157540 (CHEMBL764925) |
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| Ki | 0.5±n/a nM |
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| Citation |  Vazquez, ML; Bryant, ML; Clare, M; DeCrescenzo, GA; Doherty, EM; Freskos, JN; Getman, DP; Houseman, KA; Julien, JA; Kocan, GP Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere. J Med Chem38:581-4 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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|
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| BDBM50036257 |
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| n/a |
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| Name | BDBM50036257 |
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| Synonyms: | ((S)-1-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-butyl)-amino]-1-benzyl-2-hydroxy-propylcarbamoyl}-2-carbamoyl-ethyl)-carbamic acid pyridin-2-ylmethyl ester | CHEMBL351994 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N5O7S |
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| Mol. Mass. | 639.762 |
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| SMILES | CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccn1)S(=O)(=O)c1ccccc1 |
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| Structure | 
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