| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50036476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_64003 (CHEMBL673112) |
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| Ki | 0.011±n/a nM |
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| Citation |  Hlasta, DJ; Subramanyam, C; Bell, MR; Carabateas, PM; Court, JJ; Desai, RC; Drozd, ML; Eickhoff, WM; Ferguson, EW; Gordon, RJ Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem38:739-44 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50036476 |
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| n/a |
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| Name | BDBM50036476 |
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| Synonyms: | 2,6-Dichloro-3-(4-methyl-piperazine-1-sulfonyl)-benzoic acid 4-isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL348965 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27Cl2N3O8S2 |
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| Mol. Mass. | 620.522 |
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| SMILES | COc1cc2c(C(=O)N(COC(=O)c3c(Cl)ccc(c3Cl)S(=O)(=O)N3CCN(C)CC3)S2(=O)=O)c(c1)C(C)C |
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| Structure | 
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