Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50036478 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_64003 (CHEMBL673112) |
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Ki | 0.011±n/a nM |
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Citation | Hlasta, DJ; Subramanyam, C; Bell, MR; Carabateas, PM; Court, JJ; Desai, RC; Drozd, ML; Eickhoff, WM; Ferguson, EW; Gordon, RJ Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem38:739-44 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50036478 |
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n/a |
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Name | BDBM50036478 |
Synonyms: | 3-Carboxymethoxy-2,6-dichloro-benzoic acid 4-isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL163414 |
Type | Small organic molecule |
Emp. Form. | C21H19Cl2NO9S |
Mol. Mass. | 532.348 |
SMILES | COc1cc2c(C(=O)N(COC(=O)c3c(Cl)ccc(OCC(O)=O)c3Cl)S2(=O)=O)c(c1)C(C)C |
Structure |
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