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TargetNeutrophil elastase
LigandBDBM50037360
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63836 (CHEMBL674886)
Ki 1.4±n/a nM
Citation Bernstein, PRAndisik, DBradley, PKBryant, CBCeccarelli, CDamewood, JREarley, REdwards, PDFeeney, SGomes, BC Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones. J Med Chem37:3313-26 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50037360
n/a
NameBDBM50037360
Synonyms:2-(2-Oxo-6-phenyl-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide | CHEMBL431864
TypeSmall organic molecule
Emp. Form.C26H26F3N3O5S
Mol. Mass.549.562
SMILESCC(C)C(NC(=O)Cn1c(ccc(NS(=O)(=O)Cc2ccccc2)c1=O)-c1ccccc1)C(=O)C(F)(F)F
Structure
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