| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50037364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63836 (CHEMBL674886) |
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| Ki | 4.1±n/a nM |
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| Citation |  Bernstein, PR; Andisik, D; Bradley, PK; Bryant, CB; Ceccarelli, C; Damewood, JR; Earley, R; Edwards, PD; Feeney, S; Gomes, BC Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones. J Med Chem37:3313-26 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50037364 |
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| n/a |
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| Name | BDBM50037364 |
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| Synonyms: | CHEMBL113187 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid 2,6-dimethyl-pyridin-4-ylmethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29F3N4O5 |
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| Mol. Mass. | 558.5489 |
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| SMILES | CC(C)C(NC(=O)Cn1c(ccc(NC(=O)OCc2cc(C)nc(C)c2)c1=O)-c1ccccc1)C(=O)C(F)(F)F |
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| Structure | 
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