Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHuman immunodeficiency virus type 1 protease
LigandBDBM50037530
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159296
IC50 0.060000±n/a nM
Citation Dorsey BDLevin RBMcDaniel SLVacca JPGuare JPDarke PLZugay JAEmini EASchleif WAQuintero JC L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor. J Med Chem 37:3443-51 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50037530
n/a
NameBDBM50037530
Synonyms:(S)-4-(4-Bromo-2-mercapto-benzyl)-1-[(2S,4R)-2-hydroxy-4-((R)-(R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide | CHEMBL326600
TypeSmall organic molecule
Emp. Form.C37H47BrN4O4S
Mol. Mass.723.762
SMILESCC(C)(C)NC(=O)[C@@H]1CN(Cc2ccc(Br)cc2S)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)NC1[C@H](O)Cc2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: