| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50029613 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_159928 (CHEMBL769653) |
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| IC50 | 5±n/a nM |
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| Citation |  Reitz, DB; Li, JJ; Norton, MB; Reinhard, EJ; Collins, JT; Anderson, GD; Gregory, SA; Koboldt, CM; Perkins, WE; Seibert, K Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors. J Med Chem37:3878-81 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 69003.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI). |
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| Residue: | 604 |
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| Sequence: | MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
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| BDBM50029613 |
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| n/a |
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| Name | BDBM50029613 |
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| Synonyms: | 1-Methoxy-4-(2-(4-(methanesulfonyl)phenyl)cyclopent-1-enyl)-benzene | 1-methoxy-4-(2-(4-(methylsulfonyl)phenyl)cyclopent-1-enyl)benzene | 1-methoxy-4-[2-(4-methylsulfonylphenyl)-1-cyclopentenyl]benzene | 1-methoxy-4-{2-[4-(methylsulfonyl)phenyl]cyclopent-1-en-1-yl}benzene | 4-[2-(3,4-Dichloro-phenyl)-cyclopent-1-enyl]-benzenesulfonamide | CHEMBL108201 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20O3S |
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| Mol. Mass. | 328.425 |
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| SMILES | COc1ccc(cc1)C1=C(CCC1)c1ccc(cc1)S(C)(=O)=O |t:9| |
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| Structure | 
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