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TargetMuscarinic acetylcholine receptor M2
LigandBDBM46858
Substrate/Competitorn/a
Meas. Tech.ChEMBL_139981 (CHEMBL751167)
EC50 83±n/a nM
Citation Moltzen, EK; Pedersen, H; Bøgesø, KP; Meier, E; Frederiksen, K; Sánchez, C; Løve Lembøl, H Bioisosteres of arecoline: 1,2,3,6-tetrahydro-5-pyridyl-substituted and 3-piperidyl-substituted derivatives of tetrazoles and 1,2,3-triazoles. Synthesis and muscarinic activity. J Med Chem37:4085-99 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2
Synonyms:ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM46858
n/a
NameBDBM46858
Synonyms:1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide | ARECOLINE | ARECOLINE HYDROBROMIDE | MLS000028840 | SMR000058258 | arecoline;hydrobromide | cid_9301 | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
TypeSmall organic molecule
Emp. Form.C8H13NO2
Mol. Mass.155.1943
SMILESCOC(=O)C1=CCCN(C)C1 |t:4|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: