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TargetSterol O-acyltransferase 1
LigandBDBM50038905
Substrate/Competitorn/a
Meas. Tech.ChEMBL_28505 (CHEMBL645934)
IC50 14±n/a nM
Citation Tawada, HHarcourt, MKawamura, NKajino, MIshikawa, ESugiyama, YIkeda, HMeguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem37:2079-84 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sterol O-acyltransferase 1
Name:Sterol O-acyltransferase 1
Synonyms:ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:PROTEIN
Mol. Mass.:64165.56
Organism:Rattus norvegicus
Description:ChEMBL_28796
Residue:545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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  Blast E-value cutoff:
BDBM50038905
n/a
NameBDBM50038905
Synonyms:1-[4-(2-Chloro-phenyl)-6-isopropyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL65108
TypeSmall organic molecule
Emp. Form.C25H20ClF2N3O
Mol. Mass.451.896
SMILESCC(C)c1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1 |(4.98,-2.01,;6.32,-2.76,;6.33,-4.3,;7.65,-1.99,;7.65,-.44,;8.98,.33,;10.32,-.44,;11.64,.34,;12.98,-.43,;12.98,-1.97,;14.33,-2.74,;15.66,-1.97,;15.64,-.43,;16.99,-2.73,;16.99,-4.27,;15.66,-5.04,;15.68,-6.58,;17.02,-7.33,;17.03,-8.87,;18.35,-6.56,;18.34,-5.02,;19.67,-4.23,;11.65,-2.75,;11.65,-4.29,;10.32,-5.05,;10.32,-6.59,;11.65,-7.36,;13,-6.58,;13,-5.05,;14.49,-5.44,;10.32,-1.98,;8.99,-2.74,)|
Structure
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