Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 2 |
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Ligand | BDBM24183 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_202727 (CHEMBL809055) |
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IC50 | 5000±n/a nM |
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Citation | Dhar, TG; Borden, LA; Tyagarajan, S; Smith, KE; Branchek, TA; Weinshank, RL; Gluchowski, C Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem37:2334-42 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 2 |
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Name: | Sodium- and chloride-dependent GABA transporter 2 |
Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | S6A13_RAT | Slc6a13 |
Type: | PROTEIN |
Mol. Mass.: | 68261.89 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_70051 |
Residue: | 602 |
Sequence: | MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEGIGYASQM
IVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENAT
SPVIEFWERRVLKISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILI
LIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGASRFYDNI
EDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKSQPELTSPATPMTSLLRLTELES
NC
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BDBM24183 |
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n/a |
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Name | BDBM24183 |
Synonyms: | 4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic acid | Aminalon | CHEMBL96 | GABA | Gamma-Aminobutyric acid | [3H]GABA | cid_119 |
Type | Radiolabeled ligand |
Emp. Form. | C4H9NO2 |
Mol. Mass. | 103.1198 |
SMILES | NCCCC(O)=O |
Structure |
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