| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent betaine transporter |
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| Ligand | BDBM24183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202584 (CHEMBL806334) |
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| IC50 | 36000±n/a nM |
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| Citation |  Dhar, TG; Borden, LA; Tyagarajan, S; Smith, KE; Branchek, TA; Weinshank, RL; Gluchowski, C Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem37:2334-42 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent betaine transporter |
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| Name: | Sodium- and chloride-dependent betaine transporter |
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| Synonyms: | Betaine transporter | S6A12_HUMAN | SLC6A12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69366.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454199 |
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| Residue: | 614 |
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| Sequence: | MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGL
ASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTP
FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY
FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR
RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR
FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW
FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP
TREGLIAGEKETHL
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| BDBM24183 |
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| n/a |
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| Name | BDBM24183 |
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| Synonyms: | 4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic acid | Aminalon | CHEMBL96 | GABA | Gamma-Aminobutyric acid | [3H]GABA | cid_119 |
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| Type | Radiolabeled ligand |
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| Emp. Form. | C4H9NO2 |
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| Mol. Mass. | 103.1198 |
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| SMILES | NCCCC(O)=O |
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| Structure | 
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