Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50039499 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144466 (CHEMBL755532) |
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IC50 | 2±n/a nM |
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Citation | Neustadt, BR; Smith, EM; Nechuta, TL; Bronnenkant, AA; Haslanger, MF; Watkins, RW; Foster, CJ; Sybertz, EJ Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem37:2461-76 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85570.75 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | NEP was purified to homogeneity from rabbit kidney. |
Residue: | 750 |
Sequence: | MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGT
SWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILT
KYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAA
IVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
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BDBM50039499 |
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n/a |
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Name | BDBM50039499 |
Synonyms: | (S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-3-(4-methoxy-benzylsulfanyl)-propionic acid | CHEMBL439768 |
Type | Small organic molecule |
Emp. Form. | C21H25NO4S2 |
Mol. Mass. | 419.558 |
SMILES | COc1ccc(CSC[C@@H](NC(=O)[C@@H](CS)Cc2ccccc2)C(O)=O)cc1 |
Structure |
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