| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM50039499 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144466 (CHEMBL755532) |
|---|
| IC50 | 2±n/a nM |
|---|
| Citation |  Neustadt, BR; Smith, EM; Nechuta, TL; Bronnenkant, AA; Haslanger, MF; Watkins, RW; Foster, CJ; Sybertz, EJ Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem37:2461-76 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85570.75 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | NEP was purified to homogeneity from rabbit kidney. |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGT
SWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILT
KYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAA
IVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
|
|
|
|---|
| BDBM50039499 |
|---|
| n/a |
|---|
| Name | BDBM50039499 |
|---|
| Synonyms: | (S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-3-(4-methoxy-benzylsulfanyl)-propionic acid | CHEMBL439768 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25NO4S2 |
|---|
| Mol. Mass. | 419.558 |
|---|
| SMILES | COc1ccc(CSC[C@@H](NC(=O)[C@@H](CS)Cc2ccccc2)C(O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
