Reaction Details |
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Target | Type-1 angiotensin II receptor |
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Ligand | BDBM50039921 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_36630 (CHEMBL652869) |
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IC50 | 0.210000±n/a nM |
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Citation | Ashton, WT; Chang, LL; Flanagan, KL; Hutchins, SM; Naylor, EM; Chakravarty, PK; Patchett, AA; Greenlee, WJ; Chen, TB; Faust, KA Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity. J Med Chem37:2808-24 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor |
Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41009.15 |
Organism: | RABBIT |
Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
Residue: | 359 |
Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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BDBM50039921 |
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n/a |
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Name | BDBM50039921 |
Synonyms: | 4'-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid (3-methyl-furan-2-carbonyl)-amide | CHEMBL328941 |
Type | Small organic molecule |
Emp. Form. | C32H29F3N4O5S |
Mol. Mass. | 638.657 |
SMILES | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1occc1C |
Structure |
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