| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calpain-2 catalytic subunit |
|---|
| Ligand | BDBM50039993 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_43848 (CHEMBL658510) |
|---|
| Ki | 138±n/a nM |
|---|
| Citation |  Harbeson, SL; Abelleira, SM; Akiyama, A; Barrett, R; Carroll, RM; Straub, JA; Tkacz, JN; Wu, C; Musso, GF Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain. J Med Chem37:2918-29 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calpain-2 catalytic subunit |
|---|
| Name: | Calpain-2 catalytic subunit |
|---|
| Synonyms: | CAN2_HUMAN | CANP 2 | CANPL2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain large polypeptide L2 | Calpain-2 (m-Calpain) | Calpain-2 catalytic subunit | Calpain-2 large subunit | Calpain1/2 | M-calpain | Millimolar-calpain | calpain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 79965.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 700 |
|---|
| Sequence: | MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF
KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC
SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN
CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG
EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD
NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
|
|
|
|---|
| BDBM50039993 |
|---|
| n/a |
|---|
| Name | BDBM50039993 |
|---|
| Synonyms: | CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H31N3O4 |
|---|
| Mol. Mass. | 377.4778 |
|---|
| SMILES | CCNC(=O)CCCNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
