| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50040109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_83929 (CHEMBL693694) |
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| Ki | 12±n/a nM |
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| Citation |  Ohshima, E; Takami, H; Harakawa, H; Sato, H; Obase, H; Miki, I; Ishii, A; Ishii, H; Sasaki, Y; Ohmori, K Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1. J Med Chem36:417-20 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50040109 |
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| n/a |
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| Name | BDBM50040109 |
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| Synonyms: | 3-{11-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepin-2-yl}-propionic acid | CHEMBL134377 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H35NO3S |
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| Mol. Mass. | 501.68 |
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| SMILES | OC(=O)CCc1ccc2OCc3ccccc3C(SCCN3CCC(Cc4ccccc4)CC3)c2c1 |
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| Structure | 
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