| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50040348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28668 (CHEMBL649066) |
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| IC50 | 170±n/a nM |
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| Citation |  Buckle, DR; Arch, JR; Connolly, BJ; Fenwick, AE; Foster, KA; Murray, KJ; Readshaw, SA; Smallridge, M; Smith, DG Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem37:476-85 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
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| Type: | Protein |
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| Mol. Mass.: | 36704.13 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 326 |
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| Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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| BDBM50040348 |
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| n/a |
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| Name | BDBM50040348 |
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| Synonyms: | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-purine-2,6-dione | BRL-61063 | CHEMBL356323 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17N5O2 |
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| Mol. Mass. | 275.3064 |
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| SMILES | Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1 |
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| Structure | 
|
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