| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2, membrane associated |
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| Ligand | BDBM50040466 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_156191 (CHEMBL761442) |
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| IC50 | 65±n/a nM |
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| Citation |  Beaton, HG; Bennion, C; Connolly, S; Cook, AR; Gensmantel, NP; Hallam, C; Hardy, K; Hitchin, B; Jackson, CG; Robinson, DH Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2. J Med Chem37:557-9 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A2, membrane associated |
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| Name: | Phospholipase A2, membrane associated |
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| Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
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| Type: | Hydrolase |
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| Mol. Mass.: | 16101.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
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| Residue: | 144 |
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| Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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| BDBM50040466 |
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| n/a |
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| Name | BDBM50040466 |
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| Synonyms: | (S)-4-(4-Benzyl-phenylsulfanyl)-3-((S)-7-phenyl-heptanoylamino)-butyric acid | CHEMBL151141 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H35NO3S |
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| Mol. Mass. | 489.669 |
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| SMILES | OC(=O)C[C@@H](CSc1ccc(Cc2ccccc2)cc1)NC(=O)CCCCCCc1ccccc1 |
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| Structure | 
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