| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50041337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_152998 (CHEMBL759482) |
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| Ki | 2.4±n/a nM |
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| Citation |  Jacobs, RT; Bernstein, PR; Cronk, LA; Vacek, EP; Newcomb, LF; Aharony, D; Buckner, CK; Kusner, EJ Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orall J Med Chem37:1282-97 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39007.58 |
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| Organism: | GUINEA PIG |
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| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
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| Residue: | 340 |
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| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
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| BDBM50041337 |
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| n/a |
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| Name | BDBM50041337 |
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| Synonyms: | 3-[4-(2-Bromo-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indole-5-carboxylic acid (2-ethyl-4,4,4-trifluoro-butyl)-amide | CHEMBL26002 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31BrF3N3O5S |
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| Mol. Mass. | 694.559 |
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| SMILES | CCC(CNC(=O)c1ccc2n(C)cc(Cc3ccc(cc3OC)C(=O)NS(=O)(=O)c3ccccc3Br)c2c1)CC(F)(F)F |
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| Structure | 
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