| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50041616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65650 (CHEMBL678070) |
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| Ki | 11.3±n/a nM |
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| Citation |  Elliott, JD; Lago, MA; Cousins, RD; Gao, A; Leber, JD; Erhard, KF; Nambi, P; Elshourbagy, NA; Kumar, C; Lee, JA 1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists. J Med Chem37:1553-7 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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|
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| BDBM50041616 |
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| n/a |
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| Name | BDBM50041616 |
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| Synonyms: | (1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-phenyl)-5-propoxy-indan-2-carboxylic acid | CHEMBL39142 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26O6 |
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| Mol. Mass. | 446.4917 |
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| SMILES | CCCOc1ccc2[C@@H]([C@H]([C@@H](c2c1)c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1 |
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| Structure | 
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