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TargetEndothelin-1 receptor
LigandBDBM50041617
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65650
Ki 0.43±n/a nM
Citation Elliott JDLago MACousins RDGao ALeber JDErhard KFNambi PElshourbagy NAKumar CLee JA 1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists. J Med Chem 37:1553-7 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1 receptor
Name:Endothelin-1 receptor
Synonyms:EDNRA | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | hET-AR
Type:Enzyme Catalytic Domain
Mol. Mass.:48736.88
Organism:Homo sapiens (Human)
Description:P25101
Residue:427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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  Blast E-value cutoff:
BDBM50041617
n/a
NameBDBM50041617
Synonyms:(1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymethoxy-4-methoxy-phenyl)-5-propoxy-indan-2-carboxylic acid | 1-benzo[d][1,3]dioxol-5-ylmethyl-3-(2-carboxymethoxy-4-methoxyphenyl)-5-propoxy-(1R,3S)-2,3-dihydro-1H-2-indenecarboxylic acid | CHEMBL8823 | SB 209670 | SB-209670
TypeSmall organic molecule
Emp. Form.C29H28O9
Mol. Mass.520.5272
SMILESCCCOc1ccc2[C@@H]([C@H]([C@@H](c2c1)c1ccc(OC)cc1OCC(O)=O)C(O)=O)c1ccc2OCOc2c1
Structure
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