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TargetDihydrofolate reductase
LigandBDBM50041943
Substrate/Competitorn/a
Meas. Tech.ChEMBL_53494 (CHEMBL665618)
IC50 70±n/a nM
Citation Rosowsky, AMota, CEWright, JEFreisheim, JHHeusner, JJMcCormack, JJQueener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem36:3103-12 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Bacterial dihydrofolate reductase | DYR_ECOLI | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | folA | tmrA
Type:Enzyme
Mol. Mass.:17991.61
Organism:Escherichia coli
Description:E. coli DHFR was expressed in BL21, and purified to homogeneity.
Residue:159
Sequence:
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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BDBM50041943
n/a
NameBDBM50041943
Synonyms:6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyrimidine-2,4-diamine | 6-(2,5-dimethoxybenzyl)-5-methylthieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL104787
TypeSmall organic molecule
Emp. Form.C16H18N4O2S
Mol. Mass.330.405
SMILESCOc1ccc(OC)c(Cc2sc3nc(N)nc(N)c3c2C)c1
Structure
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