Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50041929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53494 (CHEMBL665618) |
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IC50 | 130±n/a nM |
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Citation | Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem36:3103-12 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Bacterial dihydrofolate reductase | DYR_ECOLI | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | folA | tmrA |
Type: | Enzyme |
Mol. Mass.: | 17991.61 |
Organism: | Escherichia coli |
Description: | E. coli DHFR was expressed in BL21, and purified to homogeneity. |
Residue: | 159 |
Sequence: | MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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BDBM50041929 |
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n/a |
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Name | BDBM50041929 |
Synonyms: | 6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyrimidine-2,4-diamine | 6-(2,5-dimethoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL323960 |
Type | Small organic molecule |
Emp. Form. | C15H16N4O2S |
Mol. Mass. | 316.378 |
SMILES | COc1ccc(OC)c(c1)-c1sc2nc(N)nc(N)c2c1C |
Structure |
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