Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50041944 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_158994 |
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IC50 | 5±n/a nM |
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Citation | Wonacott, A; Cooke, R; Hayes, FR; Hann, MM; Jhoti, H; McMeekin, P; Mistry, A; Murray-Rust, P; Singh, OM; Weir, MP A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies. J Med Chem36:3113-9 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50041944 |
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n/a |
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Name | BDBM50041944 |
Synonyms: | 1N-benzyl-2-[4-{3-[2-benzylcarbamoyl(benzylcarboxamido)methyl-5,5-dimethyl-(2R,4S)-1,3-thiazolan-4-ylcarboxamido]-2-hydroxypropylcarbamoyl}-3,5,5-trimethyl-(2S,4S)-tetrahydro-2-thiophenyl]-2-benzylcarboxamidoacetamide | CHEMBL430117 |
Type | Small organic molecule |
Emp. Form. | C49H60N8O7S2 |
Mol. Mass. | 937.18 |
SMILES | CC1(C)S[C@@H](NC1C(=O)NCC(O)CNC(=O)[C@@H]1N[C@H](SC1(C)C)[C@H](NC(=O)Cc1ccccc1)C(=O)NCc1ccccc1)[C@H](NC(=O)Cc1ccccc1)C(=O)NCc1ccccc1 |
Structure |
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