| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-2 (m-Calpain) |
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| Ligand | BDBM50042397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_43855 |
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| pH | 8±n/a |
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| Ki | 5.7±n/a nM |
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| Comments | extracted |
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| Citation |  Li Z; Patil GS; Golubski ZE; Hori H; Tehrani K; Foreman JE; Eveleth DD; Bartus RT; Powers JC Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. J Med Chem 36:3472-80 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-2 (m-Calpain) |
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| Name: | Calpain1/2 |
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| Synonyms: | CANP 2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain large polypeptide L2 | Calpain-2 catalytic subunit | Calpain-2 large subunit | Calpain1/2 | M-calpain | Millimolar-calpain | calpain |
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| Type: | Protein |
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| Mol. Mass.: | 79965.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 700 |
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| Sequence: | MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF
KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC
SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN
CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG
EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD
NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
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| BDBM50042397 |
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| n/a |
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| Name | BDBM50042397 |
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| Synonyms: | 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-4-phenyl-butyric acid | CHEMBL117023 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O6 |
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| Mol. Mass. | 440.4889 |
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| SMILES | CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(O)=O |
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| Structure | 
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