Reaction Details |
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Target | Calpain small subunit 1/1 catalytic subunit |
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Ligand | BDBM50042420 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_43671 (CHEMBL656204) |
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Ki | 33000±n/a nM |
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Citation | Li, Z; Patil, GS; Golubski, ZE; Hori, H; Tehrani, K; Foreman, JE; Eveleth, DD; Bartus, RT; Powers, JC Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. J Med Chem36:3472-80 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Calpain small subunit 1/1 catalytic subunit |
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Name: | Calpain small subunit 1/1 catalytic subunit |
Synonyms: | Calpain 1 | Calpain 1/small subunit 1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 43671 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Calpain small subunit 1 |
Synonyms: | CAPN4 | CAPNS | CAPNS1 | CPNS1_HUMAN | Calpain 1 |
Type: | PROTEIN |
Mol. Mass.: | 28309.36 |
Organism: | Homo sapiens (Human) |
Description: | EBI_12682 |
Residue: | 268 |
Sequence: | MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR
ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF
RAFKSLDKDGTGQIQVNIQEWLQLTMYS
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Component 2 |
Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
Type: | Protein |
Mol. Mass.: | 81880.51 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 714 |
Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM50042420 |
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n/a |
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Name | BDBM50042420 |
Synonyms: | 3-{4-Methyl-2-[4-methyl-2-(toluene-4-sulfonylamino)-pentanoylamino]-pentanoylamino}-2-oxo-pentanoic acid ethyl ester | CHEMBL3142935 |
Type | Small organic molecule |
Emp. Form. | C26H41N3O7S |
Mol. Mass. | 539.685 |
SMILES | CCOC(=O)C(=O)[C@H](CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(C)cc1 |r| |
Structure |
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