Reaction Details |
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Target | Cathepsin B |
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Ligand | BDBM50042437 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_47386 |
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pH | 5.2±n/a |
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Ki | 50000±n/a nM |
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Comments | extracted |
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Citation | Li, Z; Patil, GS; Golubski, ZE; Hori, H; Tehrani, K; Foreman, JE; Eveleth, DD; Bartus, RT; Powers, JC Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. J Med Chem36:3472-80 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin B |
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Name: | Cathepsin B |
Synonyms: | BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1 |
Type: | Enzyme |
Mol. Mass.: | 36657.87 |
Organism: | Bos taurus (bovine) |
Description: | Bovine spleen CB was purchased from Sigma Co. (USA). |
Residue: | 335 |
Sequence: | MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCG
AILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSW
NTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
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BDBM50042437 |
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n/a |
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Name | BDBM50042437 |
Synonyms: | 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-(4-chloro-phenyl)-2-oxo-butyric acid ethyl ester | CHEMBL117232 |
Type | Small organic molecule |
Emp. Form. | C26H31ClN2O6 |
Mol. Mass. | 502.987 |
SMILES | CCOC(=O)C(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 |
Structure |
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