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TargetHypoxia-inducible factor prolyl hydroxylase 4 (HIF)
LigandBDBM26114
Substrate/Competitorn/a
Meas. Tech.ChEBML_223465
IC50 5180±n/a nM
Citation Hales NJBeattie JF Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives. J Med Chem 36:3853-8 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)
Name:Hypoxia-inducible factor prolyl hydroxylase
Synonyms:Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Transmembrane prolyl 4-hydroxylase
Type:Enzyme
Mol. Mass.:56654.25
Organism:Homo sapiens (Human)
Description:Q9NXG6
Residue:502
Sequence:
MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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  Blast E-value cutoff:
BDBM26114
n/a
NameBDBM26114
Synonyms:CHEMBL88972 | pyridine carboxylate, 6b | pyridine-2,5-dicarboxylic acid
TypeSmall organic molecule
Emp. Form.C7H5NO4
Mol. Mass.167.1189
SMILESOC(=O)c1ccc(nc1)C(O)=O
Structure
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