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TargetArachidonate 5-lipoxygenase
LigandBDBM50043356
Substrate/Competitorn/a
Meas. Tech.ChEMBL_3983
IC50 7000±n/a nM
Citation Müller KGürster DPiwek SWiegrebe W Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase. J Med Chem 36:4099-107 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase
Name:Arachidonate 5-lipoxygenase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:49994.23
Organism:Bos taurus
Description:ChEMBL_157766
Residue:430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLA
CDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNG
CNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50043356
n/a
NameBDBM50043356
Synonyms:1,8-Dihydroxy-10-[2-(4-nitro-phenyl)-acetyl]-10H-anthracen-9-one | CHEMBL134069
TypeSmall organic molecule
Emp. Form.C22H15NO6
Mol. Mass.389.3576
SMILESOc1cccc2C(C(=O)Cc3ccc(cc3)[N+]([O-])=O)c3cccc(O)c3C(=O)c12
Structure
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