| Reaction Details |
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 | Report a problem with these data |
| Target | 5-lipoxygenase |
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| Ligand | BDBM50043358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_3983 (CHEMBL619256) |
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| IC50 | 3000±n/a nM |
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| Citation |  Müller, K; Gürster, D; Piwek, S; Wiegrebe, W Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase. J Med Chem36:4099-107 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-lipoxygenase |
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| Name: | 5-lipoxygenase |
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| Synonyms: | Arachidonate 5-lipoxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49994.23 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_157766 |
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| Residue: | 430 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLA
CDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNG
CNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGG
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| BDBM50043358 |
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| n/a |
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| Name | BDBM50043358 |
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| Synonyms: | (E)-1,8-Dihydroxy-10-[3-(3-methoxy-phenyl)-acryloyl]-10H-anthracen-9-one | CHEMBL433846 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18O5 |
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| Mol. Mass. | 386.3967 |
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| SMILES | COc1cccc(C=CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)c1 |w:7.6| |
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| Structure | 
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