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TargetDihydrofolate reductase
LigandBDBM50043394
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52838 (CHEMBL665043)
IC50 0.000190±n/a nM
Citation Piper, JRJohnson, CAMaddry, JAMalik, NDMcGuire, JJOtter, GMSirotnak, FM Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain. J Med Chem36:4161-71 (1994) [PubMed]
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:23891.29
Organism:Pneumocystis carinii
Description:n/a
Residue:206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM50043394
n/a
NameBDBM50043394
Synonyms:2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-naphthalene-1-carbonyl}-amino)-pentanedioic acid | CHEMBL132431
TypeSmall organic molecule
Emp. Form.C24H24N8O5
Mol. Mass.504.498
SMILESCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(O)=O)C(O)=O)c2ccccc12
Structure
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