| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50043395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54605 (CHEMBL667327) |
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| Ki | 0.00484±n/a nM |
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| Citation |  Piper, JR; Johnson, CA; Maddry, JA; Malik, ND; McGuire, JJ; Otter, GM; Sirotnak, FM Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain. J Med Chem36:4161-71 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
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|
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| BDBM50043395 |
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| n/a |
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| Name | BDBM50043395 |
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| Synonyms: | 2-({4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-methyl-amino]-naphthalene-1-carbonyl}-amino)-pentanedioic acid | CHEMBL337051 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N7O5 |
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| Mol. Mass. | 517.5365 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2c1C)c1ccc(C(=O)NC(CCC(O)=O)C(O)=O)c2ccccc12 |
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| Structure | 
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