| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50034435 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63373 (CHEMBL676109) |
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| Ki | >200000±n/a nM |
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| Citation |  Stein, PD; Hunt, JT; Floyd, DM; Moreland, S; Dickinson, KE; Mitchell, C; Liu, EC; Webb, ML; Murugesan, N; Dickey, J The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. J Med Chem37:329-31 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50034435 |
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| n/a |
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| Name | BDBM50034435 |
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| Synonyms: | 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-2,3-dihydro-oxazol-5-yl)-amide | 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide (BMS 182874) | BMS-182874 | CHEMBL267458 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N3O3S |
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| Mol. Mass. | 345.416 |
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| SMILES | CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C |
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| Structure | 
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