| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lanosterol 14-alpha demethylase |
|---|
| Ligand | BDBM31768 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_218500 (CHEMBL824123) |
|---|
| Ki | 64±n/a nM |
|---|
| Citation |  Walker, KA; Kertesz, DJ; Rotstein, DM; Swinney, DC; Berry, PW; So, OY; Webb, AS; Watson, DM; Mak, AY; Burton, PM Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J Med Chem36:2235-7 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lanosterol 14-alpha demethylase |
|---|
| Name: | Lanosterol 14-alpha demethylase |
|---|
| Synonyms: | CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56817.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16850 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKS
PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK
EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE
VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL
NLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFP
TVNYTTMIHTPENPVIRYKRRSK
|
|
|
|---|
| BDBM31768 |
|---|
| n/a |
|---|
| Name | BDBM31768 |
|---|
| Synonyms: | CHEMBL295698 | Ketoconazole | Nizoral | Panfungol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28Cl2N4O4 |
|---|
| Mol. Mass. | 531.431 |
|---|
| SMILES | CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
