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TargetLanosterol 14-alpha demethylase
LigandBDBM50161586
Substrate/Competitorn/a
Meas. Tech.ChEBML_96762
Ki 11±n/a nM
Citation Walker, KAKertesz, DJRotstein, DMSwinney, DCBerry, PWSo, OYWebb, ASWatson, DMMak, AYBurton, PM Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J Med Chem36:2235-7 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Lanosterol 14-alpha demethylase
Name:Lanosterol 14-alpha demethylase
Synonyms:CP51A_RAT | CYPLI | Cyp51 | Cyp51a1 | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14-alpha demethylase
Type:PROTEIN
Mol. Mass.:56717.47
Organism:Rattus norvegicus
Description:ChEMBL_52075
Residue:503
Sequence:
MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKS
PPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAK
EYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDE
IAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDL
NLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFP
SVNYTTMIHTPENPVIRYKRRSK
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  Blast E-value cutoff:
BDBM50161586
n/a
NameBDBM50161586
Synonyms:4-{(2S,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethylsulfanyl}-phenylamine | 4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethylsulfanyl}-phenylamine | CHEMBL70396
TypeSmall organic molecule
Emp. Form.C22H24ClN3O2S
Mol. Mass.429.963
SMILESNc1ccc(SC[C@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Structure
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