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TargetCathepsin E
LigandBDBM50045291
Substrate/Competitorn/a
Meas. Tech.ChEBML_45334
Ki 21±n/a nM
Citation Rao, CMScarborough, PEKay, JBatley, BRapundalo, SKlutchko, STaylor, MDLunney, EAHumblet, CCDunn, BM Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem36:2614-20 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Cathepsin E
Name:Cathepsin E
Synonyms:3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II
Type:Enzyme
Mol. Mass.:43298.99
Organism:Homo sapiens (Human)
Description:P14091
Residue:396
Sequence:
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50045291
n/a
NameBDBM50045291
Synonyms:CHEMBL88340 | i2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide
TypeSmall organic molecule
Emp. Form.C35H54F2N6O8S
Mol. Mass.756.9
SMILESO[C@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC=C)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1)C(F)(F)C(=O)NCCN1CCOCC1
Structure
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