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TargetMu-type opioid receptor
LigandBDBM50045767
Substrate/Competitorn/a
Meas. Tech.ChEBML_222070
Ki 1.5±n/a nM
Citation Zimmerman, DMLeander, JDCantrell, BEReel, JKSnoddy, JMendelsohn, LGJohnson, BGMitch, CH Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. J Med Chem36:2833-41 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Mu-type opioid receptor
Name:Mu-type opioid receptor
Synonyms:MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44503.11
Organism:Rattus norvegicus (rat)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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  Blast E-value cutoff:
BDBM50045767
n/a
NameBDBM50045767
Synonyms:(+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine | 3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol | 3-(3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol | 3-(trans-3,4-dimethyl-1-phenethylpiperidin-4-yl)phenol | CHEMBL319536 | N-phenethyltrans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
TypeSmall organic molecule
Emp. Form.C21H27NO
Mol. Mass.309.4452
SMILESC[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Structure
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