Reaction Details | |||
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Target | Gastrin/cholecystokinin type B receptor | ||
Ligand | BDBM50045798 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_49880 | ||
Ki | 27±n/a nM | ||
Citation | Blommaert, AG; Weng, JH; Dorville, A; McCort, I; Ducos, B; Durieux, C; Roques, BP Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties. J Med Chem36:2868-77 (1993) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gastrin/cholecystokinin type B receptor | |||
Name: | Gastrin/cholecystokinin type B receptor | ||
Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 48445.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. | ||
Residue: | 447 | ||
Sequence: |
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BDBM50045798 | |||
n/a | |||
Name | BDBM50045798 | ||
Synonyms: | CHEMBL319120 | [1-[2-(2,4-Dichloro-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | ||
Type | Small organic molecule | ||
Emp. Form. | C31H35Cl2N3O3 | ||
Mol. Mass. | 568.534 | ||
SMILES | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl |wU:21.28,19.20,23.24,wD:17.29,TLB:15:16:22:19.24.20,THB:18:17:22:19.24.20,18:19:22:16.17.25,(16.99,-12.55,;15.66,-13.33,;14.35,-14.1,;14.36,-15.66,;15.27,-16.89,;14.36,-18.15,;12.89,-17.69,;11.55,-18.46,;10.22,-17.69,;10.22,-16.13,;11.55,-15.36,;12.89,-16.13,;14.17,-12.93,;12.84,-12.16,;11.74,-13.24,;12.44,-10.67,;10.95,-10.27,;9.62,-9.47,;9.06,-8.06,;7.43,-8.21,;6.31,-9.26,;6.87,-10.67,;8.14,-11.32,;9.22,-10.27,;8.64,-8.98,;8.48,-10.58,;17.01,-14.1,;16.99,-15.63,;18.55,-14.09,;19.3,-12.76,;20.84,-12.76,;21.61,-11.42,;20.84,-10.1,;21.61,-8.77,;23.15,-8.76,;23.92,-7.43,;23.92,-10.1,;23.15,-11.43,;23.92,-12.76,)| | ||
Structure |