Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50045885 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_218704 |
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Ki | 304±n/a nM |
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Citation | Kozikowski, AP; Ma, D; Brewer, J; Sun, S; Costa, E; Romeo, E; Guidotti, A Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. J Med Chem36:2908-20 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50045885 |
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n/a |
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Name | BDBM50045885 |
Synonyms: | CHEMBL100256 | N,N-Dipropyl-2-(2-thiophen-2-yl-1H-indol-3-yl)-acetamide |
Type | Small organic molecule |
Emp. Form. | C20H24N2OS |
Mol. Mass. | 340.482 |
SMILES | CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1cccs1 |
Structure |
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